产品名称
SCGF Rabbit Polyclonal Antibody
别名
CLEC11A; CLECSF3; LSLCL; SCGF; C-type lectin domain family 11 member A; C-type lectin superfamily member 3; Lymphocyte secreted C-type lectin; Stem cell growth factor; p47
蛋白名称
C-type lectin domain family 11 member A
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6320
Human Swissprot No.
Q9Y240
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9Y240/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20256
Mouse Swissprot No.
O88200
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O88200
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29313
Rat Swissprot Link
http://www.uniprot.org/uniprot/O88201
免疫原
The antiserum was produced against synthesized peptide derived from the N-terminal region of human CLEC11A. AA range:1-50
特异性
SCGF Polyclonal Antibody detects endogenous levels of SCGF protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the C-type lectin superfamily. The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008],
组织表达
Expressed in skeletal tissues including bone marrow, chondrocytes, primary ossification center-associated cells, the perichondrium and periosteum. Lower levels of expression were detected in spleen, thymus, appendix and fetal liver.
细胞定位
Cytoplasm . Secreted .
功能
developmental stage:In the bone marrow, expression is limited to immature neutrophils. Expression was not detected in circulating mature neutrophils.,function:Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines, including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferation.,online information:Stem cell growth factor,PTM:O-glycosylated. Probably sulfated on the O-glycans.,similarity:Contains 1 C-type lectin domain.,tissue specificity:Expressed in skeletal tissues including bone marrow, chondrocytes, primary ossification center-associated cells, the perichondrium and periosteum. Lower levels of expression were detected in spleen, thymus, appendix and fetal liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
