产品名称
PNMA1 Rabbit Polyclonal Antibody
别名
Paraneoplastic antigen Ma1 (37 kDa neuronal protein) (Neuron- and testis-specific protein 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.39% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9240
Human Swissprot No.
Q8ND90
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8ND90/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/70481
Mouse Swissprot No.
Q8C1C8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8C1C8
Rat Gene Link
https://www.uniprot.org/uniprot/170636
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VHZ4
免疫原
Synthesized peptide derived from human PNMA1 AA range: 14-64
特异性
This antibody detects endogenous levels of PNMA1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a neuron- and testis-specific protein that is also expressed in some paraneoplastic syndromes affecting the nervous system. Some patients with neurologic disorders develop antibodies against the protein encoded by this gene. The identification of the antineuronal antibodies in the sera of these patients has facilitated the diagnosis of paraneoplastic neurological disorders and the early detection of the associated tumors. [provided by RefSeq, Feb 2014],
组织表达
Testis- and brain-specific. In some cancer patients, specifically expressed by paraneoplastic tumor cells.
细胞定位
Nucleus, nucleolus . In tumor cells, it is cytoplasmic.
功能
miscellaneous:Antibodies against PNMA1 are present in sera from patients suffering of paraneoplastic neurological disorders.,similarity:Belongs to the PNMA family.,subcellular location:In tumor cells, it is cytoplasmic.,tissue specificity:Testis and brain specific. In some patients suffering from cancers, it is also specifically expressed by the paraneoplastic tumor cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
