BD-PT5713

ICOS Rabbit Polyclonal Antibody

ICOS; AILIM; Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule; CD278

常规抗体

ICOS

Inducible T-cell costimulator

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

29851

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29851

Q9Y6W8

http://www.uniprot.org/uniprotkb/Q9Y6W8/entry

54167

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54167

Q9WVS0

http://www.uniprot.org/uniprot/Q9WVS0

64545

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64545

Q9R1T7

http://www.uniprot.org/uniprot/Q9R1T7

The antiserum was produced against synthesized peptide derived from the Internal region of human ICOS. AA range:31-80

ICOS Polyclonal Antibody detects endogenous levels of ICOS protein.

WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

22kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008],

Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.

[Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .

Cell adhesion molecules (CAMs);T_Cell_Receptor;Intestinal immune network for IgA production;Primary immunodeficiency;

disease:Defects in ICOS are the cause of ICOS deficiency (ICOSD) [MIM:607594]. ICOSD is a form of common variable immunodeficiency (CVID) characterized by recurrent bacterial infections of the respiratory and digestive tracts characteristic of humoral immunodeficiency. There is absence of other complicating features of CVID such as splenomegaly, autoimmune phenomena, or sarcoid-like granulomas and absence of clinical signs of overt T-cell immunodeficiency. A severe disturbance of the T-cell-dependent B-cell maturation occurs in secondary lymphoid tissue. B-cells exhibit a naive IgD+/IgM+ phenotype and the numbers of IgM memory and switched memory B-cells are substantially reduced.,function:Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.,induction:By phorbol myristate acetate (PMA) and ionomycin. Up-regulated early on T-cells and continues to be expressed into the later phases of T-cell activation.,online information:ICOS mutation db,PTM:N-glycosylated.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Homodimer; disulfide-linked.,tissue specificity:Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.