BD-PT5706

Vitronectin Rabbit Polyclonal Antibody

VTN; Vitronectin; VN; S-protein; Serum-spreading factor; V75

常规抗体

VTN

Vitronectin

WB

Human,Rat,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

7448

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7448

P04004

http://www.uniprot.org/uniprotkb/P04004/entry

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=

P29788

http://www.uniprot.org/uniprot/P29788

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=

http://www.uniprot.org/uniprot/

The antiserum was produced against synthesized peptide derived from the Internal region of human VTN. AA range:50-100

Vitronectin Polyclonal Antibody detects endogenous levels of Vitronectin protein.

WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

55kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. [provided by RefSeq, Jul 2008],

Expressed in the retina pigment epithelium (at protein level) (PubMed:25136834). Expressed in plasma (at protein level) (PubMed:2448300). Expressed in serum (at protein level) (PubMed:29567995).

Secreted, extracellular space .; Parasitophorous vacuole . (Microbial infection) In P.falciparum-infected red blood cells, VTN internalization is detected at the early trophozoite stage (PubMed:29567995). Colocalizes with SERA5 at the schizont stage and with SERA5 P47 at the merozoite surface (PubMed:29567995). .

Focal adhesion;ECM-receptor interaction;

domain:The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin.,function:Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.,function:Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.,PTM:It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.,PTM:N- and O-glycosylated.,PTM:Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading.,PTM:Sulfated on 2 tyrosine residues.,similarity:Contains 1 SMB (somatomedin-B) domain.,similarity:Contains 4 hemopexin-like domains.,subunit:Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1 and insulin.,tissue specificity:Plasma.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.