产品名称
TIM50 Rabbit Polyclonal Antibody
别名
Mitochondrial import inner membrane translocase subunit TIM50
基因名称
TIMM50 TIM50 PRO1512
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.43% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/92609
Human Swissprot No.
Q3ZCQ8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q3ZCQ8/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/66525
Mouse Swissprot No.
Q9D880
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9D880
免疫原
Synthesized peptide derived from human TIM50 AA range: 109-159
特异性
This antibody detects endogenous levels of TIM50 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a subunit of the TIM23 inner mitochondrial membrane translocase complex. The encoded protein functions as the receptor subunit that recognizes the mitochondrial targeting signal, or presequence, on protein cargo that is destined for the mitochondrial inner membrane and matrix. This protein may also play a role in maintaining the membrane permeability barrier, and knockdown of this gene in human cells results in the release of cytochrome c and apoptosis. [provided by RefSeq, Jul 2016],
组织表达
Widely expressed. Expressed at higher level in brain, kidney and liver (at protein level).
细胞定位
Mitochondrion inner membrane ; Single-pass membrane protein .; [Isoform 2]: Nucleus speckle . Nuclear and enriched in speckles with snRNPs. .
功能
domain:The FCP1 homology domain does not contain the canonical D-x-D-x-[TV] active site, suggesting that it probably does not display phosphatase activity in vivo.,function:Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Isoform 2 may participate in the release of snRNPs and SMN from the Cajal body.,sequence caution:Chimera.,similarity:Belongs to the TIM50 family.,similarity:Contains 1 FCP1 homology domain.,subcellular location:Nuclear and enriched in speckles with snRNPs.,subunit:Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50. Interacts directly with TIMM23. Isoform 2 interacts with COIL and snRNPs.,tissue specificity:Widely expressed. Expressed at higher level in brain, kidney and liver (at protein level).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
