产品名称
HGF Rabbit Polyclonal Antibody
别名
HGF; HPTA; Hepatocyte growth factor; Hepatopoietin-A; Scatter factor; SF
蛋白名称
Hepatocyte growth factor
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3082
Human Swissprot No.
P14210
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P14210/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=
Mouse Swissprot No.
Q08048
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q08048
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=
Rat Swissprot Link
http://www.uniprot.org/uniprot/
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human HGF. AA range:500-600
特异性
HGF Polyclonal Antibody detects endogenous levels of HGF protein.
稀释度
IHC-p: 100-300.WB 1:500 - 1:2000. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015],
组织表达
Brain,Embryonic fibroblast,Leukocyte,Liver,Lung fibroblast,Placenta,
细胞定位
extracellular region,extracellular space,membrane,platelet alpha granule lumen,
信号通路
Cytokine-cytokine receptor interaction;Focal adhesion;Pathways in cancer;Renal cell carcinoma;Melanoma;
功能
function:HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. It has no detectable protease activity.,online information:Hepatocyte growth factor entry,similarity:Belongs to the peptidase S1 family. Plasminogen subfamily.,similarity:Contains 1 PAN domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 4 kringle domains.,subunit:Dimer of an alpha chain and a beta chain linked by a disulfide bond.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
