BD-PT5698-Thrombospondin 2 Rabbit Polyclonal Antibody-现货抗体产品库武汉枢密脑科学技术有限公司

Thrombospondin 2 Rabbit Polyclonal Antibody

产品详情相关文献产品问答相关产品

产品基本信息

产品货号

BD-PT5698

产品名称

Thrombospondin 2 Rabbit Polyclonal Antibody

别名

THBS2; TSP2; Thrombospondin-2

类别

常规抗体

基因名称

THBS2

蛋白名称

Thrombospondin-2

推荐应用

反应种属

Human,Mouse,Rat

浓度

1 mg/ml

存储缓冲液

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

Human Gene ID

7058

Human Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7058

Human Swissprot No.

P35442

Human Swissprot Link

http://www.uniprot.org/uniprotkb/P35442/entry

Mouse Gene ID

21826

Mouse Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21826

Mouse Swissprot No.

Q03350

Mouse Swissprot Link

http://www.uniprot.org/uniprot/Q03350

Rat Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=

Rat Swissprot Link

http://www.uniprot.org/uniprot/

免疫原

The antiserum was produced against synthesized peptide derived from the C-terminal region of human THBS2. AA range:1000-1050

特异性

Thrombospondin 2 Polyclonal Antibody detects endogenous levels of Thrombospondin 2 protein.

稀释度

WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

预测分子量

130kD

运输及保存条件

-20°C/1 year

宿主

Polyclonal, Rabbit,IgG

背景介绍

thrombospondin 2(THBS2) Homo sapiens The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008],

组织表达

High expression in invertebral disk tissue.

细胞定位

extracellular region,basement membrane,extracellular matrix,platelet alpha granule,

信号通路

TGF-beta;Focal adhesion;ECM-receptor interaction;

功能

disease:Genetic variations in THBS2 may be a cause of susceptibility to lumbar disk herniation (LDH) [MIM:603932]. LDH is the predominant cause of low-back pain and unilateral leg pain.,function:Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen.,similarity:Belongs to the thrombospondin family.,similarity:Contains 1 TSP C-terminal (TSPC) domain.,similarity:Contains 1 TSP N-terminal (TSPN) domain.,similarity:Contains 1 VWFC domain.,similarity:Contains 3 EGF-like domains.,similarity:Contains 3 TSP type-1 domains.,similarity:Contains 8 TSP type-3 repeats.,subunit:Homotrimer; disulfide-linked.,tissue specificity:High expression in invertebral disk tissue.,

期货

现货

纯化

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Western blot analysis of mouse-heart lysis using THBS2 antibody. Antibody was diluted at 1:500. Secondary antibody was diluted at 1:20000

Immunohistochemical analysis of paraffin-embedded rat-testis, antibody was diluted at 1:100

Immunohistochemical analysis of paraffin-embedded Human colon. 1, Antibody was diluted at 1:200（4°,overnight）. 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200（room temperature, 30min）.