产品名称
TASK-1 Rabbit Polyclonal Antibody
别名
KCNK3; TASK; TASK1; Potassium channel subfamily K member 3; Acid-sensitive potassium channel protein TASK-1; TWIK-related acid-sensitive K(+) channel 1; Two pore potassium channel KT3.1; Two pore K(+) channel KT3.1
蛋白名称
Potassium channel subfamily K member 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3777
Human Swissprot No.
O14649
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O14649/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16527
Mouse Swissprot No.
O35111
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O35111
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29553
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54912
免疫原
The antiserum was produced against synthesized peptide derived from human TASK-1. AA range:47-96
特异性
TASK-1 Polyclonal Antibody detects endogenous levels of TASK-1 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008],
组织表达
Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon.
细胞定位
Cell membrane ; Multi-pass membrane protein .
功能
function:pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.,miscellaneous:Inhibited by external acidification. Activated by halothane and isoflurane.,similarity:Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.,tissue specificity:Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
