BD-PT5685

Dectin-2 Rabbit Polyclonal Antibody

CLEC6A; CLECSF10; DECTIN2; C-type lectin domain family 6 member A; C-type lectin superfamily member 10; Dendritic cell-associated C-type lectin 2; DC-associated C-type lectin 2; Dectin-2

常规抗体

CLEC6A

C-type lectin domain family 6 member A

WB

Human,Rat,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

93978

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=93978

Q6EIG7

http://www.uniprot.org/uniprotkb/Q6EIG7/entry

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=

Q9JKF4

http://www.uniprot.org/uniprot/Q9JKF4

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=

http://www.uniprot.org/uniprot/

Synthesized peptide derived from the Internal region of human Dectin-2.

Dectin-2 Polyclonal Antibody detects endogenous levels of Dectin-2 protein.

WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

23kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015],

Expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids.

Cell membrane ; Single-pass type II membrane protein .

function:May be involved in regulating immune reactivity.,similarity:Contains 1 C-type lectin domain.,tissue specificity:Expressed in dendritic cells.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.