BD-PM3428

CREB-1(4B4)Mouse Monoclonal Antibody

CREB1; Cyclic AMP-responsive element-binding protein 1; CREB-1; cAMP-responsive element-binding protein 1

常规抗体

CREB1

Cyclic AMP-responsive element-binding protein 1

WB

Human,Mouse,Rat

PBS, pH 7.4, containing 0.5%BSA, 0.02% New type preservative N as Preservative and 50% Glycerol.

1385

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1385

P16220

http://www.uniprot.org/uniprotkb/P16220/entry

Q01147

http://www.uniprot.org/uniprot/Q01147

Recombinant Protein of human CREB-1 AA range: 100-200

The antibody detects endogenous CREB-1 protein.

WB 1:500-1000 IHC 1:100-200. IF 1:50-200

43kD

-20°C/1 year

Monoclonal, Mouse,IgG1, kappa

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016],

Eye,Placenta,Spleen,Testis,

Nucleus .

Antigen processing and presentation;Melanogenesis;Huntington's disease;Prostate cancer;

disease:A chromosomal aberration involving CREB1 is associated with angiomatoid fibrous histiocytoma (AFH) [MIM:612160]. Translocation t(2;22)(q33;q12) with CREB1 generates a EWSR1/CREB1 fusion gene that is most common genetic abnormality in this tumor type.,function:This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transciption activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity.,PTM:Stimulated by phosphorylation. Phosphorylation of both Ser-133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP binding (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the bZIP family.,similarity:Contains 1 bZIP domain.,similarity:Contains 1 KID (kinase-inducible) domain.,subunit:Interacts with PPRC1. Binds DNA as a dimer. This dimer is stabilized by magnesium ions. Interacts, through the bZIP domain, with the coactivators TORC1/CRTC1, TORC2/CRTC2 and TORC3/CRTC3. When phosphorylated on Ser-133, binds CREBBP.,

现货

The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.