产品名称
Endoglycan Rabbit Polyclonal Antibody
别名
PODXL2; Podocalyxin-like protein 2; Endoglycan
蛋白名称
Podocalyxin-like protein 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=50512
Human Swissprot No.
Q9NZ53
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9NZ53/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=
Mouse Swissprot No.
Q8CAE9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8CAE9
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=
Rat Swissprot Link
http://www.uniprot.org/uniprot/
免疫原
Synthesized peptide derived from the Internal region of human Endoglycan.
特异性
Endoglycan Polyclonal Antibody detects endogenous levels of Endoglycan protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the CD34 family of cell surface transmembrane proteins, which are characterized by an N-terminal extracellular mucin domain, globular and stalk domains, a single pass transmembrane region, and a charged cytoplasmic tail. The encoded protein is a ligand for vascular selectins. [provided by RefSeq, Oct 2012],
组织表达
Expressed in T-cells, B-cells and monocytes. Expression is higher on memory and germinal center cells than on naive B-cells (at protein level). Highly expressed in brain. Moderately expressed in pancreas, kidney and lymphoid node. Weakly expressed in liver. Detected in both endothelial cells and CD34+ bone marrow cells.
细胞定位
Membrane ; Single-pass type I membrane protein .
功能
PTM:Glycosylated; contains chondroitin sulfate. Displays sialylated O-linked oligosaccharides.,PTM:Sulfation and sialylated O-linked oligosaccharides are necessary for SELL/L-selectin binding.,similarity:Belongs to the podocalyxin family.,subunit:Homodimer; disulfide-linked. Binds to SELL/L-selectin.,tissue specificity:Highly expressed in brain. Moderately expressed in pancreas, kidney and lymphoid node. Weakly expressed in liver. Detected in both endothelial cells and CD34+ bone marrow cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
