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PI 3-Kinase C2γ Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PT5683
产品名称
PI 3-Kinase C2γ Rabbit Polyclonal Antibody
别名
PIK3C2G; Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; PI3K-C2-gamma; PtdIns-3-kinase C2 subunit gamma; Phosphoinositide 3-kinase-C2-gamma
类别
常规抗体
基因名称
PIK3C2G
蛋白名称
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
推荐应用
WB
反应种属
Human,Rat,Mouse
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
5288
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5288
Human Swissprot No.
O75747
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O75747/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=
Mouse Swissprot No.
O70167
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O70167
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=
Rat Swissprot Link
http://www.uniprot.org/uniprot/
免疫原
Synthesized peptide derived from the N-terminal region of human PI 3-Kinase C2γ.
特异性
PI 3-Kinase C2γ Polyclonal Antibody detects endogenous levels of PI 3-Kinase C2γ protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
预测分子量
160kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],
组织表达
Highly expressed in liver, prostate and testis. Lower levels in small intestine, kidney and pancreas.
细胞定位
Membrane ; Peripheral membrane protein .
信号通路
Inositol phosphate metabolism;Phosphatidylinositol signaling system;
功能
catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.,function:In vitro, phosphorylates PtdIns and PtdIns4P but not PtdIns(4,5)P2.,similarity:Belongs to the PI3/PI4-kinase family.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PI3K/PI4K domain.,similarity:Contains 1 PX (phox homology) domain.,tissue specificity:Highly expressed in liver, prostate and testis. Lower levels in small intestine, kidney and pancreas.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Western blot analysis of A549 using PI 3-Kinase C2γ antibody.. Secondary antibody was diluted at 1:20000

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