产品名称
APP-BP2 Rabbit Polyclonal Antibody
别名
APPBP2; KIAA0228; PAT1; Amyloid protein-binding protein 2; Amyloid beta precursor protein-binding protein 2; APP-BP2; Protein interacting with APP tail 1
蛋白名称
Amyloid protein-binding protein 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10513
Human Swissprot No.
Q92624
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q92624/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66884
Mouse Swissprot No.
Q9DAX9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9DAX9
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=303396
Rat Swissprot Link
http://www.uniprot.org/uniprot/A5HK05
免疫原
Synthesized peptide derived from APP-BP2 . at AA range: 390-470
特异性
APP-BP2 Polyclonal Antibody detects endogenous levels of APP-BP2 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. The encoded protein may be involved in regulating cell death. This gene has been found to be highly expressed in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],
组织表达
Bone marrow,Cervix carcinoma,Skin,
细胞定位
Nucleus . Cytoplasm, cytoskeleton . Membrane ; Peripheral membrane protein . Associated with membranes and microtubules. .
功能
function:May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.,PTM:Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP.,similarity:Contains 8 TPR repeats.,subcellular location:Associated with membranes and microtubules.,subunit:Binds APP.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
