产品名称
SEC22B Rabbit Polyclonal Antibody
别名
SEC22B; SEC22L1; Vesicle-trafficking protein SEC22b; ER-Golgi SNARE of 24 kDa; ERS-24; ERS24; SEC22 vesicle-trafficking protein homolog B; SEC22 vesicle-trafficking protein-like 1
蛋白名称
Vesicle-trafficking protein SEC22b
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9554
Human Swissprot No.
O75396
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O75396/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20333
Mouse Swissprot No.
O08547
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O08547
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=310710
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q4KM74
免疫原
Synthesized peptide derived from the Internal region of human SEC22B.
特异性
SEC22B Polyclonal Antibody detects endogenous levels of SEC22B protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It seems to complex with SNARE and it is thought to play a role in the ER-Golgi protein trafficking. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins.[provided by RefSeq, Sep 2009],
组织表达
Caudate nucleus,Platelet,Skin,Umbilical cor
细胞定位
Endoplasmic reticulum membrane ; Single-pass type IV membrane protein . Endoplasmic reticulum-Golgi intermediate compartment membrane . Golgi apparatus, cis-Golgi network membrane . Golgi apparatus, trans-Golgi network membrane . Melanosome . Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). .
信号通路
SNARE interactions in vesicular transport;
功能
function:SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the synaptobrevin family.,similarity:Contains 1 longin domain.,similarity:Contains 1 v-SNARE coiled-coil homology domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Component of two distinct SNARE complexes consisting of STX5, GOSR2/BOS1, BET1 and SEC22B or STX18, USE1L, BNIP1/SEC20L and SEC22B. YKT6 can probably replace SEC22B in either complex.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
