产品名称
IRF-1 Rabbit Polyclonal Antibody
别名
IRF1; Interferon regulatory factor 1; IRF-1
蛋白名称
Interferon regulatory factor 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3659
Human Swissprot No.
P10914
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P10914/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16362
Mouse Swissprot No.
P15314
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P15314
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24508
Rat Swissprot Link
http://www.uniprot.org/uniprot/P23570
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human IRF1. AA range:91-140
特异性
IRF-1 Polyclonal Antibody detects endogenous levels of IRF-1 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion. [provided by RefSeq, Jul 2008],
组织表达
Pancreas,Placenta,Spleen,
细胞定位
Nucleus . Cytoplasm . MYD88-associated IRF1 migrates into the nucleus more efficiently than non-MYD88-associated IRF1. .
功能
disease:Deletion or rearrangement of IRF1 are a cause of preleukemic myelodysplastic syndrome (MDS) and of acute myelogenous leukemia (AML).,function:Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor.,induction:By viruses and IFN.,PTM:Sumoylation represses the transcriptional activity and displays enhanced resistance to protein degradation. Inactivates the tumor suppressor activity. Elevated levels in tumor cells. Major site is Lys-275. Sumoylation is enhanced by PIAS3 (By similarity). Desumoylated by SENP1 in tumor cells and appears to compete with ubiquitination on C-terminal sites.,PTM:Ubiquitinated. Appears to compete with sumoylation on C-terminal sites.,similarity:Belongs to the IRF family.,similarity:Contains 1 tryptophan pentad repeat DNA-binding domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
