产品名称
BMP-6 Rabbit Polyclonal Antibody
别名
BMP6; VGR; Bone morphogenetic protein 6; BMP-6; VG-1-related protein; VG-1-R; VGR-1
蛋白名称
Bone morphogenetic protein 6
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=654
Human Swissprot No.
P22004
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P22004/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12161
Mouse Swissprot No.
P20722
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P20722
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25644
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q04906
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human BMP6. AA range:341-390
特异性
BMP-6 Polyclonal Antibody detects endogenous levels of BMP-6 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients. [provided by RefSeq, Jul 2016],
组织表达
Bone,PCR rescued clones,
功能
function:Induces cartilage and bone formation.,online information:Bone morphogenetic protein 6 entry,similarity:Belongs to the TGF-beta family.,subunit:Interacts with SOSTDC1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.