产品名称
HOME2 Rabbit Polyclonal Antibody
别名
Homer protein homolog 2 (Homer-2) (Cupidin)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.55% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9455
Human Swissprot No.
Q9NSB8
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NSB8/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/26557
Mouse Swissprot No.
Q9QWW1
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QWW1
Rat Gene Link
https://www.uniprot.org/uniprot/29547
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O88801
免疫原
Synthesized peptide derived from human HOME2 AA range: 17-67
特异性
This antibody detects endogenous levels of HOME2 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein. Alternative splicing results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 14. [provided by RefSeq, Jun 2011],
组织表达
Brain,Frontal cortex,Lung,
细胞定位
Cytoplasm . Cell membrane . Cell junction, synapse, postsynaptic density. Cell junction, synapse. Cell projection, stereocilium . Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.
功能
domain:The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3.,function:Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.,similarity:Belongs to the Homer family.,similarity:Contains 1 WH1 domain.,subcellular location:Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.,subunit:Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
