产品名称
Probetacellulin Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=685
Human Swissprot No.
P35070
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P35070/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12223
Mouse Swissprot No.
Q05928
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q05928
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=
Rat Swissprot Link
http://www.uniprot.org/uniprot/
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human BTC. AA range:21-70
特异性
Probetacellulin Polyclonal Antibody detects endogenous levels of Probetacellulin protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients. [provided by RefSeq, Nov 2015],
组织表达
Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine.
细胞定位
[Betacellulin]: Secreted, extracellular space.; [Probetacellulin]: Cell membrane; Single-pass type I membrane protein.
功能
disease:Betacellulin from beta cells could play a role in the vascular complications associated with diabetes.,function:Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. The effects of betacellulin are probably mediated by the EGF receptor and other related receptors.,similarity:Contains 1 EGF-like domain.,subunit:Monomer.,tissue specificity:Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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