产品名称
MBNL3 Rabbit Polyclonal Antibody
别名
Muscleblind-like protein 3 (Cys3His CCG1-required protein) (Muscleblind-like X-linked protein) (Protein HCHCR)
基因名称
MBNL3 CHCR MBLX39 MBXL
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.58% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/55796
Human Swissprot No.
Q9NUK0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NUK0/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/171170
Mouse Swissprot No.
Q8R003
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R003
免疫原
Synthesized peptide derived from human MBNL3 AA range: 184-234
特异性
This antibody detects endogenous levels of MBNL3 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the muscleblind-like family of proteins. The encoded protein may function in regulation of alternative splicing and may play a role in the pathophysiology of myotonic dystrophy. Alternatively spliced transcript variants have been described. [provided by RefSeq, Dec 2009],
组织表达
Highly expressed in the placenta.
细胞定位
Nucleus . Cytoplasm . Greater concentration in the nucleus. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts.
功能
function:Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction.,similarity:Belongs to the muscleblind family.,similarity:Contains 4 C3H1-type zinc fingers.,subcellular location:Greater concentration in the nucleus. In both myotonic dystrophy 1 (DM1) and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts.,tissue specificity:Highly expressed in the placenta.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
