产品名称
CD192 Rabbit Polyclonal Antibody
别名
CCR2; CMKBR2; C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2; Monocyte chemoattractant protein 1 receptor; MCP-1-R; CD192
蛋白名称
C-C chemokine receptor type 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=729230
Human Swissprot No.
P41597
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P41597/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12772
Mouse Swissprot No.
P51683
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P51683
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=60463
Rat Swissprot Link
http://www.uniprot.org/uniprot/O55193
免疫原
The antiserum was produced against synthesized peptide derived from the N-terminal region of human CCR2. AA range:1-50
特异性
CD192 Polyclonal Antibody detects endogenous levels of CD192 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009],
组织表达
Expressed by monocytes and IL2-activated NK cells.
细胞定位
Cell membrane ; Multi-pass membrane protein . The chemoattractant receptors are distributed throughout the cell surface; after stimulation with a ligand, such as CCL2, they are rapidly recruited into microdomain clusters at the cell membrane. .
信号通路
Cytokine-cytokine receptor interaction;Chemokine;
功能
function:Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.,online information:CC chemokine receptors entry,polymorphism:Variations in CCR2 are associated with relative resistance to immunodeficiency virus type 1 (resistance to HIV-1) [MIM:609423].,PTM:N-glycosylated.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Binds to HIV-1 Tat.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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