BD-PT5634

CD305 Rabbit Polyclonal Antibody

LAIR1; CD305; Leukocyte-associated immunoglobulin-like receptor 1; LAIR-1; hLAIR1; CD305

常规抗体

LAIR1

Leukocyte-associated immunoglobulin-like receptor 1

WB

Human,Rat,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

3903

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3903

Q6GTX8

http://www.uniprot.org/uniprotkb/Q6GTX8/entry

52855

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=52855

Q8BG84

http://www.uniprot.org/uniprot/Q8BG84

574531

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=574531

P0C1X9

http://www.uniprot.org/uniprot/P0C1X9

The antiserum was produced against synthesized peptide derived from the Internal region of human LAIR1. AA range:21-70

CD305 Polyclonal Antibody detects endogenous levels of CD305 protein.

WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

32kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],

Expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cells. Abnormally low expression in naive B-cells from HIV-1 infected patients. Very low expression in NK cells from a patient with chronic active Epstein-Barr virus infection.

Cell membrane ; Single-pass type I membrane protein .

developmental stage:Complete loss of expression when naive B-cells proliferates and differentiates into Ig-producing plasma cells under in vitro stimulation.,domain:ITIM (immunoreceptor tyrosine-based inhibitor motif) motif is a cytoplasmic motif present in 2 copies in the intracellular part of LAIR1. When phosphorylated, ITIM motif can bind the SH2 domain of several SH2-containing phosphatases, leading to down-regulation of cell activation.,function:Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, downregulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.,induction:By T-cell receptor stimulation in a process that requires p38 MAP kinase and ERK signaling.,PTM:N-glycosylated.,PTM:Phosphorylation at Tyr-251 and Tyr-281 activates it. May be phosphorylated by LCK.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,subunit:Interacts with SH2 domains of tyrosine-protein phosphatases PTPN6 and PTPN11. The interaction with PTPN6 is constitutive. Interacts with the SH2 domain of CSK.,tissue specificity:Expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cells. Abnormally low expression in naive B-cells from HIV-1 infected patients. Very low expression in NK cells from a patient with chronic active Epstein-Barr virus infection.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.