BD-PT5628

CD155 Rabbit Polyclonal Antibody

PVR; PVS; Poliovirus receptor; Nectin-like protein 5; NECL-5; CD155

常规抗体

PVR

Poliovirus receptor

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

5817

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5817

P15151

http://www.uniprot.org/uniprotkb/P15151/entry

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=

http://www.uniprot.org/uniprot/

The antiserum was produced against synthesized peptide derived from the Internal region of human PVR. AA range:81-130

CD155 Polyclonal Antibody detects endogenous levels of CD155 protein.

WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000 Not yet tested in other applications.

70kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008],

Liver,Pancreas,Placenta,Plasma,

[Isoform Alpha]: Cell membrane; Single-pass type I membrane protein.; [Isoform Delta]: Cell membrane; Single-pass type I membrane protein.; [Isoform Beta]: Secreted.; [Isoform Gamma]: Secreted.

Cell adhesion molecules (CAMs);

function:Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.,induction:Transcriptionally regulated by SHH.,miscellaneous:The V-type domain is necessary and sufficient for virus binding and uptake.,online information:The accidental crippler - Issue 75 of October 2006,similarity:Belongs to the nectin family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Can form trans-heterodimers with PVRL3/nectin-3. The extracellular domain interacts with VTN, CD226 and CD96. The cytoplasmic domain interacts with DYNLT1. Interacts with HHV-5 UL141. Interacts with poliovirus capsid composed of VP1, VP2 and VP3, mainly through VP3. Binds with high affinity to TIGIT.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.