产品名称
Ox40L Rabbit Polyclonal Antibody
别名
TNFSF4; TXGP1; Tumor necrosis factor ligand superfamily member 4; Glycoprotein Gp34; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; CD252
蛋白名称
Tumor necrosis factor ligand superfamily member 4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7292
Human Swissprot No.
P23510
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P23510/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22164
Mouse Swissprot No.
P43488
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P43488
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=89814
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9Z2P3
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human TNFSF4. AA range:31-80
特异性
Ox40L Polyclonal Antibody detects endogenous levels of Ox40L protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-1:300. IF 1:100-1:300. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],
细胞定位
Membrane; Single-pass type II membrane protein.
信号通路
Cytokine-cytokine receptor interaction;
功能
disease:Genetic variation in TNFSF4 influences susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.,function:Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.,induction:By human T-cell leukemia virus type I transactivator P40-TAX.,similarity:Belongs to the tumor necrosis factor family.,subunit:Homotrimer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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