产品名称
IL-13Rα2 Rabbit Polyclonal Antibody
别名
IL13RA2; IL13R; Interleukin-13 receptor subunit alpha-2; IL-13 receptor subunit alpha-2; IL-13R subunit alpha-2; IL-13R-alpha-2; IL-13RA2; Interleukin-13-binding protein; CD213a2
蛋白名称
Interleukin-13 receptor subunit alpha-2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3598
Human Swissprot No.
Q14627
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q14627/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=
Mouse Swissprot No.
O88786
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O88786
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=
Rat Swissprot Link
http://www.uniprot.org/uniprot/
免疫原
Synthesized peptide derived from Interleukin-13 receptor subunit alpha-2 at AA range: 241-290
特异性
IL-13Rα2 Polyclonal Antibody detects endogenous levels of IL-13Rα2 protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008],
组织表达
Brain,Lung,Prostate,Renal cell carcinoma,Testis,
细胞定位
Membrane; Single-pass type I membrane protein.
功能
domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:Binds as a monomer with high affinity to interleukin 13 (IL13), but not to IL4.,similarity:Belongs to the type I cytokine receptor family. Type 5 subfamily.,similarity:Contains 1 fibronectin type-III domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.