产品名称
FBX32 Rabbit Polyclonal Antibody
别名
F-box only protein 32 (Atrogin-1) (Muscle atrophy F-box protein) (MAFbx)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.66% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/114907
Human Swissprot No.
Q969P5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q969P5/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/67731
Mouse Swissprot No.
Q9CPU7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CPU7
Rat Gene Link
https://www.uniprot.org/uniprot/171043
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q91Z62
免疫原
Synthesized peptide derived from human FBX32 AA range: 217-267
特异性
This antibody detects endogenous levels of FBX32 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011],
组织表达
Specifically expressed in cardiac and skeletal muscle.
细胞定位
Cytoplasm . Nucleus . Shuttles between cytoplasm and the nucleus.
功能
function:Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 F-box domain.,subunit:Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO32) formed of CUL1, SKP1A, RBX1 and FBXO32.,tissue specificity:Specifically expressed in cardiac and skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
