产品名称
GAP-43(Mix)Mouse Monoclonal Antibody
别名
GAP43; Neuromodulin; Axonal membrane protein GAP-43; Growth-associated protein 43; Neural phosphoprotein B-50; pp46
存储缓冲液
PBS, pH 7.4, containing 0.5%BSA, 0.02% New type preservative N as Preservative and 50% Glycerol.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2596
Human Swissprot No.
P17677
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P17677/entry
Mouse Swissprot No.
P06837
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P06837
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P07936
免疫原
Recombinant Protein of GAP-43
特异性
The antibody detects endogenous GAP-43 protein.
稀释度
WB 1:1000-2000 IHC 1:200-500. IF 1:50-200
背景介绍
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Alzheimer cortex,Brain,Subthalamic nucleus,
细胞定位
Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, growth cone membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction, synapse . Cell projection, filopodium membrane ; Peripheral membrane protein . Perikaryon . Cell projection, dendrite . Cell projection, axon . Cytoplasm . Cytoplasmic surface of growth cone and synaptic plasma membranes. .
功能
function:This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons.,online information:Gap-43 entry,PTM:Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.,similarity:Belongs to the neuromodulin family.,similarity:Contains 1 IQ domain.,subcellular location:Cytoplasmic surface of growth cone and synaptic plasma membranes.,subunit:Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.,
纯化
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
