产品名称
Nectin 2 Rabbit Polyclonal Antibody
别名
PVRL2; HVEB; PRR2; Poliovirus receptor-related protein 2; Herpes virus entry mediator B; Herpesvirus entry mediator B; HveB; Nectin-2; CD112
蛋白名称
Poliovirus receptor-related protein 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5819
Human Swissprot No.
Q92692
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q92692/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=
Mouse Swissprot No.
P32507
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P32507
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=
Rat Swissprot Link
http://www.uniprot.org/uniprot/
免疫原
Synthesized peptide derived from Poliovirus receptor-related protein 2 at AA range: 151-200
特异性
Nectin 2 Polyclonal Antibody detects endogenous levels of Nectin 2 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],
细胞定位
Cell membrane; Single-pass type I membrane protein.
信号通路
Cell adhesion molecules (CAMs);Adherens_Junction;
功能
function:Probable cell adhesion protein.,similarity:Belongs to the nectin family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Can form trans-heterodimers with PVRL3/nectin-3 (By similarity). Interacts with CD226. Receptor for alphaherpesvirus (HSV-1, HSV-2 and pseudorabies virus) entry into cells. Binds with low affinity to TIGIT.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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