产品名称
GNAI2 Rabbit Polyclonal Antibody
别名
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.68% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/2771
Human Swissprot No.
P04899
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P04899/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/14678
Mouse Swissprot No.
P08752
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P08752
Rat Gene Link
https://www.uniprot.org/uniprot/81664
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P04897
免疫原
Synthesized peptide derived from human GNAI2 AA range: 274-324
特异性
This antibody detects endogenous levels of GNAI2 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013],
组织表达
Brain,Cerebellum,Kidney,Lung,Mammary gland,Testis,
细胞定位
Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cell membrane . Membrane ; Lipid-anchor . Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody.
功能
function:Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli.,similarity:Belongs to the G-alpha family. G(i/o/t/z) subfamily.,subunit:G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with GPSM1 (By similarity). Interacts with UNC5B.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
