BD-PT5593

P-Selectin Rabbit Polyclonal Antibody

SELP; GMRP; GRMP; P-selectin; CD62 antigen-like family member P; Granule membrane protein 140; GMP-140; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; Platelet activation dependent granule-external membrane protein; PADGEM; CD62P

常规抗体

SELP

P-selectin

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

6403

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6403

P16109

http://www.uniprot.org/uniprotkb/P16109/entry

20344

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20344

Q01102

http://www.uniprot.org/uniprot/Q01102

25651

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25651

P98106

http://www.uniprot.org/uniprot/P98106

The antiserum was produced against synthesized peptide derived from the N-terminal region of human SELP. AA range:81-130

P-Selectin Polyclonal Antibody detects endogenous levels of P-Selectin protein.

WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

91kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008],

Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.

Cell membrane ; Single-pass type I membrane protein .

Cell adhesion molecules (CAMs);

disease:Defects in SELP may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.,function:Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.,online information:P-selectin,similarity:Belongs to the selectin/LECAM family.,similarity:Contains 1 C-type lectin domain.,similarity:Contains 1 EGF-like domain.,similarity:Contains 9 Sushi (CCP/SCR) domains.,subunit:Interacts with SNX17. Interacts with PSGL1/SEPL and mediateS neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope and specific tyrosine sulfation on PSGL1.,tissue specificity:Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.