产品名称
CD42d Rabbit Polyclonal Antibody
别名
GP5; Platelet glycoprotein V; GPV; Glycoprotein 5; CD42d
蛋白名称
Platelet glycoprotein V
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2814
Human Swissprot No.
P40197
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P40197/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=
Mouse Swissprot No.
O08742
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O08742
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25259
Rat Swissprot Link
http://www.uniprot.org/uniprot/O08770
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human GP5. AA range:331-380
特异性
CD42d Polyclonal Antibody detects endogenous levels of CD42d protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]).[supplied by OMIM, Nov 2010],
组织表达
Platelets and megakaryocytes.
细胞定位
Membrane; Single-pass type I membrane protein.
信号通路
ECM-receptor interaction;Hematopoietic cell lineage;
功能
function:The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis.,PTM:The N-terminus is blocked.,similarity:Contains 14 LRR (leucine-rich) repeats.,tissue specificity:Platelets and megakaryocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
