产品名称
CD39 Rabbit Polyclonal Antibody
别名
ENTPD1; CD39; Ectonucleoside triphosphate diphosphohydrolase 1; NTPDase 1; Ecto-ATP diphosphohydrolase 1; Ecto-ATPDase 1; Ecto-ATPase 1; Ecto-apyrase; Lymphoid cell activation antigen; CD39
蛋白名称
Ectonucleoside triphosphate diphosphohydrolase 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=953
Human Swissprot No.
P49961
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P49961/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12495
Mouse Swissprot No.
P55772
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P55772
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64519
Rat Swissprot Link
http://www.uniprot.org/uniprot/P97687
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human ENTPD1. AA range:31-80
特异性
CD39 Polyclonal Antibody detects endogenous levels of CD39 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer anticancer benefits. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015],
组织表达
Expressed primarily on activated lymphoid cells. Also expressed in endothelial tissues. Isoform 1 and isoform 3 are present in both placenta and umbilical vein, whereas isoform 2 is present in placenta only.
细胞定位
Membrane ; Multi-pass membrane protein .
信号通路
Purine metabolism;Pyrimidine metabolism;
功能
catalytic activity:ATP + 2 H(2)O = AMP + 2 phosphate.,cofactor:Calcium.,cofactor:Magnesium.,function:In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation. Hydrolyzes ATP and ADP equally well.,PTM:Palmitoylated in the N-terminal part.,PTM:The N-terminus is blocked.,similarity:Belongs to the GDA1/CD39 NTPase family.,subunit:Homodimer; disulfide-linked.,tissue specificity:Expressed primarily on activated lymphoid cells. Also expressed in endothelial tissues. The vascular isoform and the placental isoform II are present in both placenta and umbilical vein, whereas placental isoform I is present in placenta only.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
