产品名称
AL2CL Rabbit Polyclonal Antibody
别名
ALS2 C-terminal-like protein
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.222% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/259173
Human Swissprot No.
Q60I27
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q60I27/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/235633
Mouse Swissprot No.
Q60I26
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q60I26
免疫原
Synthesized peptide derived from human AL2CL AA range: 606-656
特异性
This antibody detects endogenous levels of AL2CL at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
组织表达
Expressed in heart and kidney.
细胞定位
Cytoplasm . Distributed onto the vesicular compartments in the cytoplasm with strong punctated staining. Colocalizes with RAB5A onto the vesicular/membranous compartments in the cytoplasm, particularly to the leading edges of the cells.
功能
function:Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics.,similarity:Contains 1 VPS9 domain.,similarity:Contains 8 MORN repeats.,subcellular location:Distributed onto the vesicular compartments in the cytoplasm with strong punctated staining. Colocalizes with RAB5A onto the vesicular/membranous compartments in the cytoplasm, particularly to the leading edges of the cells.,subunit:Homodimer. Forms a heteromeric complex with ALS2 (By similarity). Interacts with ALS2 and RAB5A.,tissue specificity:Expressed in heart and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
