产品名称
STX5 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.74% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/6811
Human Swissprot No.
Q13190
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q13190/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/56389
Mouse Swissprot No.
Q8K1E0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K1E0
Rat Gene Link
https://www.uniprot.org/uniprot/65134
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q08851
免疫原
Synthesized peptide derived from human STX5 AA range: 233-283
特异性
This antibody detects endogenous levels of STX5 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011],
组织表达
B-cell,Heart,Kidney,Umbilical cord blood,Uterus,
细胞定位
Endoplasmic reticulum-Golgi intermediate compartment membrane ; Single-pass type IV membrane protein . Golgi apparatus membrane . Localizes throughout the Golgi apparatus, but most abundant in the cis-most cisternae. .
功能
function:Mediates endoplasmic reticulum to Golgi transport (By similarity). Golgi apparatus membrane; Single-pass type IV membrane protein .,similarity:Belongs to the syntaxin family.,similarity:Contains 1 t-SNARE coiled-coil homology domain.,subunit:Part of a ternary complex containing STX5A, NSFL1C and VCP. Identified in a unique SNARE complex composed of the Golgi SNAREs GOSR1, GOSR2 and YKT6.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
