产品名称
SOD-2 Rabbit Polyclonal Antibody
别名
SOD2; Superoxide dismutase [Mn], mitochondrial
蛋白名称
Superoxide dismutase [Mn] mitochondrial
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6648
Human Swissprot No.
P04179
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P04179/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20656
Mouse Swissprot No.
P09671
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P09671
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24787
Rat Swissprot Link
http://www.uniprot.org/uniprot/P07895
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human SOD2. AA range:91-140
特异性
SOD-2 Polyclonal Antibody detects endogenous levels of SOD-2 protein.
稀释度
IHC-p: 100-300.WB 1:500 - 1:2000. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016],
组织表达
Brain,Colon,Heart,Liver,Lung,Mammary carcinoma,Tongue,
细胞定位
Mitochondrion matrix.
信号通路
Huntington's disease;
功能
catalytic activity:2 superoxide + 2 H(+) = O(2) + H(2)O(2).,cofactor:Binds 1 manganese ion per subunit.,disease:Genetic variation in SOD2 is associated with susceptibility to diabetic nephropathy [MIM:612634]; also called susceptibility to microvascular complications of diabetes type 6 (MVCD6). Diabetic nephropathy is a kidney disease and resultant kidney function impairment due to the long standing effects of diabetes on the microvasculature (glomerulus) of the kidney. Features include increased urine protein and declining kidney function.,function:Destroys radicals which are normally produced within the cells and which are toxic to biological systems.,online information:Superoxide dismutase entry,online information:The Singapore human mutation and polymorphism database,PTM:Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.,similarity:Belongs to the iron/manganese superoxide dismutase family.,subunit:Homotetramer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
