产品名称
CD89 Rabbit Polyclonal Antibody
别名
FCAR; CD89; Immunoglobulin alpha Fc receptor; IgA Fc receptor; CD89
蛋白名称
Immunoglobulin alpha Fc receptor
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2204
Human Swissprot No.
P24071
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P24071/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=
Rat Swissprot Link
http://www.uniprot.org/uniprot/
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human FCAR. AA range:31-80
特异性
CD89 Polyclonal Antibody detects endogenous levels of CD89 protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],
组织表达
Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces.
细胞定位
[Isoform A.1]: Cell membrane; Single-pass type I membrane protein.; [Isoform A.2]: Cell membrane; Single-pass type I membrane protein.; [Isoform A.3]: Cell membrane; Single-pass type I membrane protein.; [Isoform B]: Secreted.; [Isoform B-delta-S2]: Secreted.
功能
alternative products:Additional isoforms seem to exist,function:Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Associates with the Fc epsilon RI gamma 2 receptor inducing tyrosine phosphorylation of gamma 2.,tissue specificity:Differentially expressed between blood and mucosal myeloid cells. Monocytes express isoform A.1, isoform A.2 and isoform A.3 while alveolar macrophages express isoform A.1 and isoform A.2; however they express only one isoform at their surfaces.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
