产品名称
IGFBP1 Rabbit Polyclonal Antibody
别名
IGFBP1; IBP1; Insulin-like growth factor-binding protein 1; IBP-1; IGF-binding protein 1; IGFBP-1; Placental protein 12; PP12
蛋白名称
Insulin-like growth factor-binding protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3484
Human Swissprot No.
P08833
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P08833/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16006
Mouse Swissprot No.
P47876
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P47876
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25685
Rat Swissprot Link
http://www.uniprot.org/uniprot/P21743
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human IGFBP1. AA range:91-140
特异性
IGFBP1 Polyclonal Antibody detects endogenous levels of IGFBP1 protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008],
组织表达
Amniotic fluid,Decidua,Liver,Placenta,Skin,
功能
function:IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.,PTM:Phosphorylated; probably by casein kinase II. Alters the affinity of the protein for IGFs.,similarity:Contains 1 IGFBP N-terminal domain.,similarity:Contains 1 thyroglobulin type-1 domain.,subunit:Binds equally well IGF1 and IGF2.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
