产品名称
OSGI1 Rabbit Polyclonal Antibody
别名
Oxidative stress-induced growth inhibitor 1 (Ovary, kidney and liver protein 38) (huOKL38) (Pregnancy-induced growth inhibitor OKL38)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.77% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/29948
Human Swissprot No.
Q9UJX0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UJX0/entry
免疫原
Synthesized peptide derived from human OSGI1 AA range: 276-326
特异性
This antibody detects endogenous levels of OSGI1 at Human
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011],
组织表达
Ubiquitous. Highest expression in the ovary, testis, kidney, skeletal muscle and liver (PubMed:11459809, PubMed:14570898, PubMed:15569677). Weakly expressed in spleen, heart, kidney, and pancreas (PubMed:15569677). Highly expressed in tumor cells (at protein level) (PubMed:15569677).
功能
function:Regulates the differentiation and proliferation of normal cells through the regulation of cell death.,induction:By pregnancy.,miscellaneous:Loss of OSGIN1 protein disturbs the balance between cell growth, differentiation, and cell death in normal tissue, resulting in uncontrolled growth and formation of tumors.,similarity:Belongs to the OKL38 family.,tissue specificity:Ubiquitous. Highest expression in the ovary, testis, kidney, and liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
