产品名称
FGF-17 Rabbit Polyclonal Antibody
别名
FGF17; Fibroblast growth factor 17; FGF-17
蛋白名称
Fibroblast growth factor 17
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8822
Human Swissprot No.
O60258
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O60258/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=
Mouse Swissprot No.
P63075
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P63075
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=
Rat Swissprot Link
http://www.uniprot.org/uniprot/
免疫原
The antiserum was produced against synthesized peptide derived from the C-terminal region of human FGF17. AA range:267-216
特异性
FGF-17 Polyclonal Antibody detects endogenous levels of FGF-17 protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the fibroblast growth factor (FGF) family. Member of the FGF family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is expressed during embryogenesis and in the adult cerebellum and cortex and may be essential for vascular growth and normal brain development. Mutations in this gene are the cause of hypogonadotropic hypogonadism 20 with or without anosmia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015],
组织表达
Preferentially expressed in the embryonic brain.
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;Regulates Actin and Cytoskeleton;Pathways in cancer;Melanoma;
功能
developmental stage:Detected in embryos at E14.5, but not at E10.5 and E19.5. Preferentially expressed in the neuroepithelia of the isthmus and septum of the embryonic brain at E14.5.,function:May be a signaling molecule in the induction and patterning of the embryonic brain.,similarity:Belongs to the heparin-binding growth factors family.,tissue specificity:Preferentially expressed in the embryonic brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
.jpg)
