BD-PT5550

ApoC-III Rabbit Polyclonal Antibody

APOC3; Apolipoprotein C-III; Apo-CIII; ApoC-III; Apolipoprotein C3

常规抗体

APOC3

Apolipoprotein C-III

WB

Human,Rat,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

345

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=345

P02656

http://www.uniprot.org/uniprotkb/P02656/entry

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=

P33622

http://www.uniprot.org/uniprot/P33622

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=

http://www.uniprot.org/uniprot/

The antiserum was produced against synthesized peptide derived from the C-terminal region of human APOC3. AA range:46-95

ApoC-III Polyclonal Antibody detects endogenous levels of ApoC-III protein.

WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

11kD

-20°C/1 year

Polyclonal, Rabbit,IgG

Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008],

Liver.

Secreted .

PPAR;

disease:Defects in APOC3 may be a cause of hyperalphalipoproteinemia [MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL).,function:Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.,PTM:O-linked glycan consists of Gal-GalNAc disaccharide, further modified with up to 3 sialic acid residues.,similarity:Belongs to the apolipoprotein C3 family.,tissue specificity:Constitutes 50% of the protein fraction of VLDL and 2% of that of HDL. Synthesized predominantly in liver and to a lesser degree in intestine.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.