产品名称
NOD1 Rabbit Polyclonal Antibody
别名
Nucleotide-binding oligomerization domain-containing protein 1 (Caspase recruitment domain-containing protein 4)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.224% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10392
Human Swissprot No.
Q9Y239
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y239/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/107607
Mouse Swissprot No.
Q8BHB0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BHB0
免疫原
Synthesized peptide derived from human NOD1 AA range: 290-340
特异性
This antibody detects endogenous levels of NOD1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5' UTR have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Oct 2009],
组织表达
Highly expressed in adult heart, skeletal muscle, pancreas, spleen and ovary. Also detected in placenta, lung, liver, kidney, thymus, testis, small intestine and colon.
细胞定位
Cytoplasm. Cell membrane . Apical cell membrane. Basolateral cell membrane. Detected in the cytoplasm and at the cell membrane. Following bacterial infection, localizes to bacterial entry sites in the cell membrane. Recruited to the basolateral and apical membranes in polarized epithelial cells.
功能
function:Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS).,similarity:Contains 1 CARD domain.,similarity:Contains 1 NACHT domain.,similarity:Contains 9 LRR (leucine-rich) repeats.,subunit:Self-associates. Binds to caspase-9 and RIPK2 by CARD-CARD interaction.,tissue specificity:Highly expressed in adult heart, skeletal muscle, pancreas, spleen and ovary. Also detected in placenta, lung, liver, kidney, thymus, testis, small intestine and colon.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
