BD-PT5548-Tenascin-C Rabbit Polyclonal Antibody-现货抗体产品库武汉枢密脑科学技术有限公司

Tenascin-C Rabbit Polyclonal Antibody

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产品基本信息

产品货号

BD-PT5548

产品名称

Tenascin-C Rabbit Polyclonal Antibody

别名

TNC; HXB; Tenascin; TN; Cytotactin; GMEM; GP 150-225; Glioma-associated-extracellular matrix antigen; Hexabrachion; JI; Myotendinous antigen; Neuronectin; Tenascin-C; TN-C

类别

常规抗体

基因名称

TNC

蛋白名称

Tenascin

推荐应用

反应种属

Human,Mouse,Rat

浓度

1 mg/ml

存储缓冲液

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

Human Gene ID

3371

Human Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3371

Human Swissprot No.

P24821

Human Swissprot Link

http://www.uniprot.org/uniprotkb/P24821/entry

Mouse Gene ID

21923

Mouse Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21923

Mouse Swissprot No.

Q80YX1

Mouse Swissprot Link

http://www.uniprot.org/uniprot/Q80YX1

Rat Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=

Rat Swissprot Link

http://www.uniprot.org/uniprot/

免疫原

The antiserum was produced against synthesized peptide derived from the C-terminal region of human TNC. AA range:2151-2200

特异性

Tenascin-C Polyclonal Antibody detects endogenous levels of Tenascin-C protein.

稀释度

WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

预测分子量

240kD

运输及保存条件

-20°C/1 year

宿主

Polyclonal, Rabbit,IgG

背景介绍

tenascin C(TNC) Homo sapiens This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011],

组织表达

Brain,Fetal brain,Fetal cartilage,Glioblastoma,Human fetal kidney,Liver,Melanoma,Milk,Plasma,

细胞定位

Secreted, extracellular space, extracellular matrix.

信号通路

Focal adhesion;ECM-receptor interaction;

功能

alternative products:Isoforms are produced in a tissue- and time-specific manner during development,function:Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.,induction:By TGF-beta.,PTM:N-glycosylated.,similarity:Belongs to the tenascin family.,similarity:Contains 1 fibrinogen C-terminal domain.,similarity:Contains 15 EGF-like domains.,similarity:Contains 15 fibronectin type-III domains.,subunit:Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4.,

期货

现货

纯化

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Western Blot analysis of KB cells using Tenascin-C Polyclonal Antibody. Antibody was diluted at 1:1000. Secondary antibody was diluted at 1:20000

Immunohistochemical analysis of paraffin-embedded human-kidney, antibody was diluted at 1:100

Immunohistochemical analysis of paraffin-embedded Human kidney. 1, Antibody was diluted at 1:200（4°,overnight）. 2, High-pressure and temperature EDTA, pH8.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200（room temperature, 30min）.