产品名称
VGLU1 Rabbit Polyclonal Antibody
别名
Vesicular glutamate transporter 1 (VGluT1) (Brain-specific Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 7)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.79% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/57030
Human Swissprot No.
Q9P2U7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9P2U7/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/72961
Mouse Swissprot No.
Q3TXX4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3TXX4
Rat Gene Link
https://www.uniprot.org/uniprot/116638
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q62634
免疫原
Synthesized peptide derived from human VGLU1 AA range: 488-538
特异性
This antibody detects endogenous levels of VGLU1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family. [provided by RefSeq, Jul 2008],
组织表达
Expressed in several regions of the brain including amygdala, cerebellum, cerebral cortex, hippocampus, frontal lobe, medulla, occipital lobe, putamen and temporal lobe.
细胞定位
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane . Membrane ; Multi-pass membrane protein . Cell junction, synapse, synaptosome .
功能
function:Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.,similarity:Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.,tissue specificity:Expressed in several regions of the brain including amygdala, cerebellum, cerebral cortex, hippocampus, frontal lobe, medulla, occipital lobe, putamen and temporal lobe.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
