产品名称
PSMD1 Rabbit Polyclonal Antibody
别名
26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.225% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5707
Human Swissprot No.
Q99460
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q99460/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/70247
Mouse Swissprot No.
Q3TXS7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3TXS7
Rat Gene Link
https://www.uniprot.org/uniprot/83806
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O88761
免疫原
Synthesized peptide derived from human PSMD1 AA range: 192-242
特异性
This antibody detects endogenous levels of PSMD1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes the largest non-ATPase subunit of the 19S regulator lid, which is responsible for substrate recognition and binding. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2010],
组织表达
Cervix,Epithelium,Hepatocyte,Liver,Lymph,Placenta,Testis,Uterus,
细胞定位
proteasome complex,nucleus,nucleoplasm,cytosol,proteasome regulatory particle,proteasome regulatory particle, base subcomplex,membrane,integral component of membrane,proteasome accessory complex,proteasome storage granule,extracellular exosome,
功能
function:Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the proteasome subunit S1 family.,similarity:Contains 10 PC repeats.,subunit:Interacts with ADRM1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
