产品名称
OAS2 Rabbit Polyclonal Antibody
别名
OAS2; 2'-5'-oligoadenylate synthase 2; (2-5')oligo(A) synthase 2; 2-5A synthase 2; p69 OAS / p71 OAS; p69OAS / p71OAS
蛋白名称
2'-5'-oligoadenylate synthase 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4939
Human Swissprot No.
P29728
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P29728/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=246728
Mouse Swissprot No.
E9Q9A9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/E9Q9A9
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=363938
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q5MYU0
免疫原
The antiserum was produced against synthesized peptide derived from the N-terminal region of human OAS2. AA range:61-110
特异性
OAS2 Polyclonal Antibody detects endogenous levels of OAS2 protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
2'-5'-oligoadenylate synthetase 2(OAS2) Homo sapiens This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008],
组织表达
Blood,Colon,Testis,Uterus,
细胞定位
Cytoplasm . Cytoplasm, perinuclear region .
功能
catalytic activity:Binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs.,function:May play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis.,induction:By interferons.,similarity:Belongs to the 2-5A synthetase family.,subcellular location:Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.,subunit:Homodimer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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