产品名称
ALR Rabbit Polyclonal Antibody
别名
GFER; ALR; HERV1; HPO; FAD-linked sulfhydryl oxidase ALR; Augmenter of liver regeneration; hERV1; Hepatopoietin
蛋白名称
FAD-linked sulfhydryl oxidase ALR
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2671
Human Swissprot No.
P55789
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P55789/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11692
Mouse Swissprot No.
P56213
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P56213
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27100
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q63042
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human GFER. AA range:51-100
特异性
ALR Polyclonal Antibody detects endogenous levels of ALR protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. [provided by RefSeq, Jul 2008],
组织表达
Ubiquitously expressed. Highest expression in the testis and liver and low expression in the muscle.
细胞定位
[Isoform 1]: Mitochondrion intermembrane space. Mitochondrion .; [Isoform 2]: Cytoplasm. Secreted.
功能
catalytic activity:4 R'C(R)SH + O(2) = 2 R'C(R)S-S(R)CR' + 2 H(2)O.,cofactor:FAD.,function:FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation.,similarity:Contains 1 ERV/ALR sulfhydryl oxidase domain.,subunit:Homodimer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
