产品名称
ARI3B Rabbit Polyclonal Antibody
别名
AT-rich interactive domain-containing protein 3B (ARID domain-containing protein 3B) (Bright and dead ringer protein) (Bright-like protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.83% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10620
Human Swissprot No.
Q8IVW6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8IVW6/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/56380
Mouse Swissprot No.
Q9Z1N7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Z1N7
免疫原
Synthesized peptide derived from human ARI3B AA range: 459-509
特异性
This antibody detects endogenous levels of ARI3B at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008],
组织表达
Expressed in placenta, testis and leukocytes. Expressed in neuroblastoma. Present in K-562 erythrocytic leukemia cell line (at protein level).
功能
function:Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A.,similarity:Contains 1 ARID domain.,subunit:Heterodimer with ARID3A. Interacts with unphosphorylated RB1.,tissue specificity:Expressed in placenta, testis and leukocytes. Expressed in neuroblastoma. Present in K562 erythrocytic leukemia cells (at protein level).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
