BD-PT5520

TRPC3 Rabbit Polyclonal Antibody

TRPC3; TRP3; Short transient receptor potential channel 3; TrpC3; Transient receptor protein 3; TRP-3; hTrp-3; hTrp3

常规抗体

TRPC3

Short transient receptor potential channel 3

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

7222

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7222

Q13507

http://www.uniprot.org/uniprotkb/Q13507/entry

Q9QZC1

http://www.uniprot.org/uniprot/Q9QZC1

Q9JMI9

http://www.uniprot.org/uniprot/Q9JMI9

The antiserum was produced against synthesized peptide derived from the Internal region of human TRPC3. AA range:411-460

TRPC3 Polyclonal Antibody detects endogenous levels of TRPC3 protein.

WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

97kD

-20°C/1 year

Polyclonal, Rabbit,IgG

transient receptor potential cation channel subfamily C member 3(TRPC3) Homo sapiens The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],

Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis.

Membrane; Multi-pass membrane protein.

function:Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol-1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.,similarity:Belongs to the transient receptor family. STrpC subfamily.,similarity:Contains 5 ANK repeats.,subunit:Interacts with TRPC1. Interacts with ITPR3. Interacts with MX1 and RNF24.,tissue specificity:Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.