产品名称
MAG Rabbit Polyclonal Antibody
别名
MAG; GMA; Myelin-associated glycoprotein; Siglec-4a
蛋白名称
Myelin-associated glycoprotein
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4099
Human Swissprot No.
P20916
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P20916/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17136
Mouse Swissprot No.
P20917
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P20917
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29409
Rat Swissprot Link
http://www.uniprot.org/uniprot/P07722
免疫原
The antiserum was produced against synthesized peptide derived from the C-terminal region of human MAG. AA range:501-550
特异性
MAG Polyclonal Antibody detects endogenous levels of MAG protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2010],
组织表达
Both isoform 1 and isoform 2 are detected in myelinated structures in the central and peripheral nervous system, in periaxonal myelin and at Schmidt-Lanterman incisures (PubMed:9495552, PubMed:6200494). Detected in optic nerve, in oligodendroglia and in periaxonal myelin sheaths (PubMed:6200494). Detected in compact myelin (at protein level) (PubMed:6200494). Both isoform 1 and isoform 2 are detected in the central and peripheral nervous system (PubMed:9495552).
细胞定位
Cell membrane ; Single-pass type I membrane protein . Membrane raft .
信号通路
Cell adhesion molecules (CAMs);
功能
function:Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3-linked sialic acid.,online information:Siglec-4,similarity:Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 4 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Binds to RTN4R.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
