产品名称
INDOL1 Rabbit Polyclonal Antibody
别名
IDO2; INDOL1; Indoleamine 2,3-dioxygenase 2; IDO-2; Indoleamine 2,3-dioxygenase-like protein 1; Indoleamine-pyrrole 2,3-dioxygenase-like protein 1
蛋白名称
Indoleamine 2,3-dioxygenase 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=169355
Human Swissprot No.
Q6ZQW0
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q6ZQW0/entry
Mouse Swissprot No.
Q8R0V5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8R0V5
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human IDO2. AA range:101-150
特异性
INDOL1 Polyclonal Antibody detects endogenous levels of INDOL1 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011],
组织表达
Detected in liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon (PubMed:17671174). Also expressed at low level in testis and thyroid. Not expressed in the majority of human tumor samples (>99%) (PubMed:25691885).
细胞定位
cytoplasm,cytosol,integral component of membrane,
信号通路
Tryptophan metabolism;
功能
tryptophan metabolic process,?tryptophan catabolic process,?cellular amino acid derivative metabolic process,?biogenic amine metabolic process,?indolalkylamine metabolic process,?cellular amino acid catabolic process,?aromatic amino acid family metabolic process,?aromatic amino acid family catabolic process,?amine catabolic process,?organic acid catabolic process,?aromatic compound catabolic process,?tryptophan catabolic process to kynurenine,?cellular amino acid derivative catabolic process,?biogenic amine catabolic process,?indole and derivative metabolic process,?indole derivative metabolic process,?indole derivative catabolic process,?indolalkylamine catabolic process,?carboxylic acid catabolic process,?heterocycle catabolic process,?oxidation reduction,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
