产品名称
TRAIL Rabbit Polyclonal Antibody
别名
TNFSF10; APO2L; TRAIL; Tumor necrosis factor ligand superfamily member 10; Apo-2 ligand; Apo-2L; TNF-related apoptosis-inducing ligand; Protein TRAIL; CD253
蛋白名称
Tumor necrosis factor ligand superfamily member 10
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8743
Human Swissprot No.
P50591
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P50591/entry
Mouse Swissprot No.
P50592
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P50592
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human TNFSF10. AA range:31-80
特异性
TRAIL Polyclonal Antibody detects endogenous levels of TRAIL protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provi
组织表达
Widespread; most predominant in spleen, lung and prostate.
细胞定位
Cell membrane ; Single-pass type II membrane protein . Secreted . Exists both as membrane-bound and soluble form. .
信号通路
Cytokine-cytokine receptor interaction;Apoptosis_Inhibition;Apoptosis_Mitochondrial;Apoptosis_Overview;Natural killer cell mediated cytotoxicity;
功能
cofactor:Binds 1 zinc ion per trimer.,function:Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.,similarity:Belongs to the tumor necrosis factor family.,subunit:Homotrimer.,tissue specificity:Widespread; most predominant in spleen, lung and prostate.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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